📃 Paper Title: Urinary Concentrations and Antibacterial Activities of Nitroxoline at 250 Milligrams versus Trimethoprim at 200 Milligrams against Uropathogens in Healthy Volunteers
🧍 Author: Wagenlehner
🕒 Year: 2014
📚 Journal: Antimicrobial Agents and Chemotherapy
🌎 Country: Germany
ㅤContext to the study:
Can you tell me about a study that assessed the antibacterial activities of antibiotic drugs in different urinary pH values?
ㅤ✅ Take-home message of study:
This trial investigated the urinary concentrations of Nitroxoline 250 Milligrams versus Trimethoprim 200 Milligrams and their antibacterial activities (urinary inhibitory titers [UITs] and urinary bactericidal titers [UBTs]) against uropathogens at three different urinary pH values within 24 h in six healthy volunteers after a single oral dose.
Nitroxoline is a more active antibacterial in acidic urine, while trimethoprim is more active in alkaline urine.
The urinary inhibitory titers and urinary bactericidal titers of nitroxoline were generally lower than those of trimethoprim.
Nitroxoline exhibited mainly bacteriostatic activity in urine. TMP showed both bacteriostatic and bactericidal activity.
ㅤ Randomized crossover study
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Study participants:
Inclusion criteria:
Healthy volunteers for investigation for urinary inhibitory titers (UIT), urinary bactericidal titers (UBT) and urinary bactericidal kinetics (UBK).
Study Size:
9 participants: Six healthy volunteers (three caucasian men and women) investigated for urinary inhibitory titers (UIT) and urinary bactericidal titers (UBT). Three additional volunteers (two caucasian women and one man) were investigated for urinary bactericidal kinetics (UBK).
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Key study outcomes:
Urinary inhibitory titers
Urinary bactericidal titers
Urinary bactericidal kinetics
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Study Limitations:
The cumulative effects of multiple doses or inhibition of bacterial adherence was not evaluated,
Low number of included participants
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